America's Byways and National Wildlife Refuges
Little Dixie Highway of the Great River Road (Missouri)

Little Dixie Highway offers an ever-changing panorama as it winds along the Mississippi River. Limestone bluffs provide stunning views in the National Register Districts of Clarksville and Louisiana, home of artist colonies and antiques galore. History buffs, art lovers, and antique hounds find a haven in this riverfront setting that also houses three wildlife refuges. See a variety of birds at Clarence Cannon National Wildlife Refuge, which supports diverse species of waterfowl, wading birds, shorebirds, and songbirds. The 11,600-acre Great River National Wildlife Refuge's wetlands, open water, bottomland forests, and grasslands welcome numerous mammals, amphibians, reptiles, fish, and hundreds of bird species. Find a range of wildlife at the Mark Twain National Wildlife Refuge Complex, home to several species of migratory birds and native wildlife such as deer, fox, beaver, frogs, turtles, and snakes.

Learn more about Little Dixie Highway of the Great River Road